Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | RORB | Q92753 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6246669 | 0.89 | PDE4D (0.54) | PDE4DRORCRORBHSP90AA1HSP90AB1 | |
| SCHEMBL6934114 | 0.86 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1PDE4BTUBB4ATUBB | |
| SCHEMBL16712923 | 0.85 | LMNA (0.51) | HSP90AA1HSP90AB1TSHRSMN1; SMN2HDAC8 | |
| SCHEMBL16158860 | 0.84 | RORC (0.50) | PDE4DRORCRORBHSP90AA1HSP90AB1 | |
| SCHEMBL16712926 | 0.84 | POLB (0.49) | MAPTSMN1; SMN2HDAC8ERN1SMPD1 | |
| SCHEMBL3467803 | 0.83 | PDE4D (0.52) | PDE4DRORCRORBHSP90AA1HSP90AB1 | |
| SCHEMBL7553675 | 0.82 | RARA (0.58) | PDE4DPDE4BTUBB4ATUBBTUBA3C | |
| SCHEMBL5099550 | 0.81 | PDE4D (0.56) | PDE4DRORCRORBPDE4BNPC1 | |
| SCHEMBL16712928 | 0.81 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1NPC1MAPTTSHR | |
| SCHEMBL8024587 | 0.81 | PDE4D (0.55) | PDE4DRORCRORBHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160272584-A1 | BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015070091-A1 | BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS | THE UNIVERSITY OF KANSAS (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272584-A1 | BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | PDE4D 2888/4885RORC 3047/4885RORB 2439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.