Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | COMT | P21964 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720809 | 0.79 | KDM4E (0.45) | KDM1ACASP6TSHRMETAP1ALDH1A1 | |
| SCHEMBL17653997 | 0.74 | ADORA2A (0.54) | TSHRALDH1A1L3MBTL1 | |
| SCHEMBL17654018 | 0.73 | CYP1A2 (0.48) | TSHRALDH1A1 | |
| SCHEMBL2373481 | 0.72 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1 | |
| SCHEMBL16720179 | 0.72 | QDPR (0.39) | ALDH1A1L3MBTL1 | |
| SCHEMBL16720501 | 0.72 | CYP2A6 (0.48) | CYP19A1ALDH1A1L3MBTL1 | |
| SCHEMBL679952 | 0.72 | CYP19A1 (0.55) | KDM1ACASP6CYP19A1TSHRALDH1A1 | |
| SCHEMBL31551042 | 0.72 | CYP19A1 (0.55) | KDM1ACASP6CYP19A1TSHRALDH1A1 | |
| SCHEMBL16719631 | 0.71 | CDC7 (0.51) | — | |
| SCHEMBL159940 | 0.71 | ALDH1A1 (0.54) | HDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |