Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | QDPR | P09417 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720559 | 0.82 | MMP3 (0.38) | KDM4ERPS6KA3NPC1RAB9A | |
| SCHEMBL16720286 | 0.73 | PDGFRB (0.42) | MAP4K4ROCK1DYRK1ACLK4PDGFRB | |
| SCHEMBL28663547 | 0.69 | NPC1 (0.52) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL16719975 | 0.67 | KDM4A (0.32) | — | |
| SCHEMBL16720591 | 0.66 | TYR (0.47) | CDK8DYRK1ADYRK1BKDM4E | |
| SCHEMBL2397171 | 0.65 | MAPT (0.42) | PDGFRBPDGFRALMNAMAPTKDM4E | |
| SCHEMBL28326772 | 0.65 | CYP11B1 (0.44) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL16720516 | 0.63 | QDPR (0.36) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL16720650 | 0.63 | QDPR (0.36) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL1960709 | 0.62 | MAPT (0.65) | MAP4K4CDK8CLK2CDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |