Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720488 | 0.86 | ABL1 (0.41) | ESR2NPC1RAB9AABL1ABCB1 | |
| SCHEMBL16720142 | 0.83 | BACE1 (0.46) | NPC1RAB9AKDM4EALDH1A1ABL1 | |
| SCHEMBL16428843 | 0.75 | CYP1A1 (0.53) | ESR2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4284645 | 0.75 | KDM1A (0.42) | ESR2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16720127 | 0.74 | COMT (0.40) | ESR2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16720157 | 0.73 | ESR2 (0.50) | ESR2PTGS1HSD17B1HSD17B2TRPM8 | |
| SCHEMBL16720131 | 0.71 | ESR2 (0.47) | ESR2NPC1RAB9APTGS1HSD17B1 | |
| SCHEMBL16720083 | 0.71 | ESR2 (0.47) | ESR2PTGS1HSD17B1HSD17B2FYN | |
| SCHEMBL16720427 | 0.71 | PDGFRB (0.45) | NPC1RAB9AKDM4EALDH1A1PTGS1 | |
| SCHEMBL16719967 | 0.71 | CYP1A1 (0.42) | ESR2KDM4EALDH1A1FYNRELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |