Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284645 | 0.88 | KDM1A (0.42) | ABL1BCRABCB1HSD17B1HSD17B2 | |
| SCHEMBL16720142 | 0.87 | BACE1 (0.46) | ABL1BCRABCB1CYP3A4CYP2C9 | |
| SCHEMBL16719944 | 0.86 | ESR2 (0.44) | ABL1BCRABCB1HSD17B1HSD17B2 | |
| SCHEMBL4281437 | 0.78 | HDAC4 (0.40) | ABL1BCRABCB1HSD17B1HSD17B2 | |
| SCHEMBL16720127 | 0.77 | COMT (0.40) | ABL1BCRABCB1CYP3A4CYP2C9 | |
| SCHEMBL16720354 | 0.74 | HSD17B1 (0.48) | ABL1BCRABCB1HSD17B1HSD17B2 | |
| SCHEMBL1027189 | 0.73 | HDAC4 (0.62) | ABL1BCRABCB1HSD17B1HSD17B2 | |
| SCHEMBL16720143 | 0.73 | MEN1 (0.51) | ABL1BCRABCB1ESR1MAPK1 | |
| SCHEMBL21296972 | 0.72 | ABL1 (0.73) | ABL1BCRABCB1HSD17B1HSD17B2 | |
| SCHEMBL1026075 | 0.72 | HSD17B1 (0.68) | ABL1BCRABCB1HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |