Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720508 | 0.88 | HSD17B1 (0.47) | ESR2HSD17B1HSD17B2LMNA | |
| SCHEMBL16720654 | 0.84 | ESR1 (0.37) | ESR2HSD17B1HSD17B2MAPTMEN1 | |
| SCHEMBL12488049 | 0.84 | TAAR1 (0.41) | ESR2HSD17B1HSD17B2TAAR1MAPT | |
| SCHEMBL16720083 | 0.83 | ESR2 (0.47) | ESR2HSD17B1HSD17B2TAAR1TRPM8 | |
| SCHEMBL16720516 | 0.74 | QDPR (0.36) | ESR2MAPTLMNAALOX15NFKB1 | |
| SCHEMBL16719944 | 0.73 | ESR2 (0.44) | ESR2HSD17B1HSD17B2TRPM8PTGS1 | |
| SCHEMBL10494072 | 0.73 | TAAR1 (0.41) | ESR2HSD17B1HSD17B2TAAR1MAPT | |
| SCHEMBL9646878 | 0.70 | TAAR1 (0.39) | ESR2HSD17B1HSD17B2TAAR1MEN1 | |
| SCHEMBL16720131 | 0.70 | ESR2 (0.47) | ESR2HSD17B1HSD17B2TAAR1PTGS1 | |
| SCHEMBL16719547 | 0.70 | ESR2 (0.47) | ESR2HSD17B1HSD17B2TAAR1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |