Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.55 |
| ▸ | CDK8 | P49336 | 11/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31064990 | 0.77 | CDK8 (0.64) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL858203 | 0.77 | CDK8 (0.64) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL16719750 | 0.75 | NPC1 (0.50) | — | |
| SCHEMBL4831501 | 0.75 | CDK8 (0.81) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL16720494 | 0.72 | TYR (0.46) | BTK | |
| SCHEMBL16720660 | 0.72 | BRD4 (0.38) | AXLNUDT1 | |
| SCHEMBL27699368 | 0.72 | CDK8 (0.67) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL16720011 | 0.72 | RIPK1 (0.55) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL296946 | 0.71 | RIPK1 (0.66) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL22978455 | 0.71 | RIPK1 (1.00) | RIPK1CDK8AXLPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |