Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768655 | 0.82 | FOLH1 (0.47) | TP53TSHRHSD17B10CA12CA1 | |
| SCHEMBL16720405 | 0.80 | KMO (0.50) | CA12CA1CA2CA9CA6 | |
| SCHEMBL159940 | 0.79 | ALDH1A1 (0.54) | KDM4EHSD17B10BCL2L1HDAC4HDAC2 | |
| SCHEMBL16719637 | 0.79 | ESR1 (0.42) | TP53KDM4ELMNAHSD17B10CA12 | |
| SCHEMBL16720203 | 0.76 | ALOX5 (0.41) | LMNAHSD17B10CA12CA9MAPT | |
| SCHEMBL9988102 | 0.76 | BACE1 (0.38) | TP53HSD17B10CA12CA9BCL2L1 | |
| SCHEMBL6669375 | 0.76 | PIK3CA (0.35) | KDM4EHSD17B10CA9CA14CA6 | |
| SCHEMBL3238016 | 0.75 | CA12 (0.61) | TP53TSHRKDM4ELMNAHSD17B10 | |
| SCHEMBL29133892 | 0.74 | TP53 (0.57) | TP53TSHRKDM4ELMNAHSD17B10 | |
| SCHEMBL298629 | 0.74 | BCL2L1 (0.58) | TP53TSHRKDM4ELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |