Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 13/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 12/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15477525 | 0.79 | KMO (0.45) | CYP19A1 | |
| SCHEMBL11107619 | 0.79 | METAP2 (0.45) | METAP2 | |
| SCHEMBL16720064 | 0.79 | KMO (0.45) | CYP3A4CYP17A1CYP11B1CYP11B2ESR2 | |
| SCHEMBL557899 | 0.77 | KMT2A (0.41) | METAP2 | |
| SCHEMBL3654046 | 0.71 | CYP1A2 (0.47) | CYP2C9CYP19A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL989535 | 0.70 | CYP2A6 (0.52) | CYP3A4CYP2C9METAP2CYP19A1CYP1A2 | |
| SCHEMBL30862097 | 0.70 | HSD17B1 (0.66) | HSD17B1HSD17B2CYP3A4CYP2C9METAP2 | |
| SCHEMBL1899480 | 0.69 | HSD17B1 (0.58) | HSD17B1HSD17B2CYP3A4CYP2C9METAP2 | |
| SCHEMBL20566349 | 0.69 | HSD17B1 (0.58) | HSD17B1HSD17B2CYP3A4CYP2C9METAP2 | |
| SCHEMBL17626014 | 0.69 | KMO (0.49) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |