Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HK1 | P19367 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720555 | 0.84 | LMNA (0.40) | MGAMGAASIMGAM2 | |
| SCHEMBL16720507 | 0.83 | ALOX5 (0.40) | ADORA3MAPTHK1HTTHKDC1 | |
| SCHEMBL4527701 | 0.77 | CYP2A6 (0.39) | KDM4EGAA | |
| SCHEMBL4527458 | 0.76 | KDM4E (0.36) | KDM4EMAPTMEN1KMT2A | |
| SCHEMBL28015705 | 0.73 | KDM4E (0.38) | KDM4EADORA3MGAMGAASI | |
| SCHEMBL16720456 | 0.73 | BRD4 (0.40) | MEN1KMT2A | |
| SCHEMBL2165945 | 0.69 | KDM4E (0.38) | KDM4EADORA3MGAMGAASI | |
| SCHEMBL2091081 | 0.69 | NPC1 (0.42) | KDM4EGAAMAPTHTTMEN1 | |
| SCHEMBL6826494 | 0.69 | MAP4K4 (0.39) | KDM4EADORA3MAPTMEN1KMT2A | |
| SCHEMBL2012944 | 0.68 | MGAM (0.42) | MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |