Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720220 | 0.81 | CYP1A2 (0.50) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL31041151 | 0.75 | KIF11 (0.79) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| Lithium SCHEMBL31041154 | 0.73 | KIF11 (0.76) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL12054668 | 0.73 | KEAP1 (0.75) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL16720458 | 0.70 | CA2 (0.54) | KIF11CA12CA1CA2CA9 | |
| SCHEMBL4661398 | 0.69 | KIF11 (0.68) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL873846 | 0.69 | KEAP1 (0.75) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL21254711 | 0.69 | KIF11 (0.68) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL4666107 | 0.67 | KIF11 (0.66) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL4659812 | 0.67 | KIF11 (0.66) | KIF11ALDH1A1HPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |