Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.36 |
| ▸ | TDO2 | P48775 | 3/20 | 0.35 |
| ▸ | METAP2 | P50579 | 3/20 | 0.34 |
| ▸ | METAP1 | P53582 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607926 | 0.79 | METAP1 (0.39) | IDO1TDO2METAP2METAP1KDM4E | |
| SCHEMBL16720573 | 0.79 | METAP2 (0.36) | IDO1TDO2METAP2METAP1KDM4E | |
| SCHEMBL16720677 | 0.75 | SCN9A (0.35) | IDO1TDO2METAP2METAP1HSD17B10 | |
| SCHEMBL1800346 | 0.74 | ALDH1A1 (0.46) | IDO1TDO2METAP2METAP1HSD17B10 | |
| SCHEMBL16720204 | 0.72 | KDM4E (0.38) | IDO1TDO2METAP2METAP1HSD17B10 | |
| SCHEMBL4518539 | 0.72 | LMNA (0.53) | IDO1TDO2METAP2METAP1HSD17B10 | |
| Bromide SCHEMBL7959477 | 0.71 | ALDH1A1 (0.43) | IDO1TDO2METAP2METAP1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6765946 | 0.71 | ALDH1A1 (0.43) | IDO1TDO2METAP2METAP1HSD17B10 | |
| SCHEMBL999087 | 0.69 | METAP1 (0.40) | IDO1TDO2METAP2METAP1HSD17B10 | |
| SCHEMBL1868592 | 0.69 | SCN9A (0.40) | IDO1TDO2METAP2METAP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372776-B1 | Arylpiperidine derivatives | PFIZER (US) | 1996-09-25 | — | — | EP | claimed |
| US-5153206-A | Neuroleptic agents for treating psychological disorders | PFIZER INC. (US) | 1992-10-06 | — | — | US | claimed |
| WO-1990006303-A1 | ARYLPIPERIDINE DERIVATIVES | PFIZER INC. (US) | 1990-06-14 | — | — | WO | claimed |
| EP-0372776-A2 | Arylpiperidine derivatives | PFIZER INC. (US) | 1990-06-13 | — | — | EP | claimed |
| JP-2275853-A | — | — | None | — | — | JP | disclosed |
| EP-0372776-B1 | Arylpiperidine derivatives | PFIZER (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5294619-A | N-(nitrogen-containing heterocyclylalkyl-phenyl-piperidines | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5153206-A | Neuroleptic agents for treating psychological disorders | PFIZER INC. (US) | 1992-10-06 | — | — | US | disclosed |
| JP-H02275853-A | ARYLPIPERIDINE DERIVATIVE | PFIZER INC | 1990-11-09 | — | — | JP | disclosed |
| WO-1990006303-A1 | ARYLPIPERIDINE DERIVATIVES | PFIZER INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| EP-0372776-A2 | Arylpiperidine derivatives | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |