Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318359 | 0.85 | HTR3A (0.44) | HTR6HTR3ADRD2HTR1D | |
| SCHEMBL4318361 | 0.85 | HTR3A (0.44) | HTR6HTR3ADRD2HTR1D | |
| SCHEMBL701006 | 0.84 | HTR3A (0.43) | HTR6HTR3ADRD2HTR1D | |
| SCHEMBL1673073 | 0.84 | CHRM2 (0.40) | CHRNA7SIGMAR1HTR1D | |
| SCHEMBL700099 | 0.82 | MEN1 (0.48) | HTR6HTR3ADRD2HTR1D | |
| SCHEMBL700100 | 0.82 | MEN1 (0.48) | HTR6HTR3ADRD2HTR1D | |
| Lithium Ion SCHEMBL700947 | 0.81 | HTR3A (0.42) | HTR6HTR3ADRD2HTR1D | |
| SCHEMBL1672448 | 0.74 | SIGMAR1 (0.39) | HTR3ACHRNA7SIGMAR1HTR1D | |
| SCHEMBL1672248 | 0.73 | SIGMAR1 (0.40) | HTR3ACHRNA7SIGMAR1 | |
| SCHEMBL1672243 | 0.73 | SIGMAR1 (0.38) | HTR3ACHRNA7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310019-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | Albany Molecular Research, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2009155054-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2009-12-23 | — | — | WO | disclosed |