Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16723248 | 0.78 | HSD11B1 (0.43) | TSHRGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL16723156 | 0.77 | HCRTR2 (0.34) | GAAMEN1KMT2AHCRTR2 | |
| SCHEMBL16723104 | 0.73 | GAA (0.35) | TSHRGAASMN1; SMN2 | |
| SCHEMBL16723162 | 0.73 | IDH1 (0.37) | TSHRGAASMN1; SMN2 | |
| SCHEMBL16723246 | 0.73 | TSHR (0.64) | TSHRGAAHSD11B1 | |
| SCHEMBL16723238 | 0.70 | SMN1; SMN2 (0.41) | TSHRGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL16723225 | 0.67 | OPRK1 (0.38) | GAAOPRK1 | |
| SCHEMBL16723230 | 0.67 | TSHR (0.37) | TSHRGAA | |
| SCHEMBL8260839 | 0.66 | NAMPT (0.45) | OPRM1OPRL1NAMPTKMT2AHSD11B1 | |
| SCHEMBL8260851 | 0.66 | NAMPT (0.45) | OPRM1OPRL1NAMPTKMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015074081-A1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | BAIR KENNETH W (US) | 2015-05-21 | — | — | WO | disclosed |