Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAPDH | P04406 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670909 | 0.68 | PTGS2 (0.40) | RAB9ASMN1; SMN2BRD4MAPTHSD17B10 | |
| SCHEMBL1670700 | 0.65 | ERN1 (0.40) | BRD4CREBBPBRD2 | |
| SCHEMBL11611224 | 0.65 | HSD17B10 (0.50) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL11759468 | 0.65 | HSD17B10 (0.50) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL11755257 | 0.64 | HSD17B10 (0.53) | RAB9ALMNATSHRNFKB1NFKB2 | |
| Water SCHEMBL9344643 | 0.62 | HSD17B10 (0.73) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL27751423 | 0.62 | LMNA (0.49) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL5945230 | 0.62 | HSD17B10 (0.58) | LMNATP53PKMMAPTTHRB | |
| SCHEMBL25284190 | 0.62 | HSD17B10 (0.50) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL11750060 | 0.61 | HSD17B10 (0.49) | RAB9ALMNATSHRNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |