Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14985490 | 0.82 | IDO1 (0.50) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL14985492 | 0.82 | IDO1 (0.58) | MAPTLMNATP53IDO1L3MBTL1 | |
| SCHEMBL14985512 | 0.81 | CA12 (0.50) | MAPTALOX15SMN1; SMN2LMNAMEN1 | |
| SCHEMBL1696565 | 0.81 | L3MBTL1 (0.63) | ALOX15LMNATP53RAB9APIM1 | |
| SCHEMBL14985496 | 0.81 | ALDH1A1 (0.50) | LMNAHPGDIDO1L3MBTL1NOTUM | |
| SCHEMBL3344891 | 0.81 | METAP2 (0.49) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6652224 | 0.77 | IDO1 (0.52) | MAPTLMNAMAPK1HPGDIDO1 | |
| SCHEMBL14985523 | 0.76 | COMT (0.44) | SMN1; SMN2LMNANPC1RAB9AHPGD | |
| SCHEMBL3344889 | 0.76 | TTK (0.49) | MAPTPIM1CYP2D6CYP2A6CYP2C9 | |
| SCHEMBL18179682 | 0.75 | LMNA (0.50) | LMNACASP1HPGDCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073763-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |