Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735673 | 0.87 | PDK1 (0.49) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735633 | 0.85 | PDK1 (0.41) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735623 | 0.85 | SCD5 (0.44) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735561 | 0.85 | PDK1 (0.48) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735598 | 0.85 | PDK1 (0.43) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735666 | 0.81 | LMNA (0.53) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735601 | 0.77 | PDK1 (0.62) | PDK1PDK2PDK3PDK4HDAC6 | |
| SCHEMBL16735668 | 0.77 | PDK1 (0.51) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735572 | 0.77 | PDK1 (0.51) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL2331996 | 0.75 | GPBAR1 (0.74) | GPBAR1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |