Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 8/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 8/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 8/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 8/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735633 | 0.88 | PDK1 (0.41) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL16735561 | 0.88 | PDK1 (0.48) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL16735623 | 0.88 | SCD5 (0.44) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL16735598 | 0.87 | PDK1 (0.43) | PDK1PDK2PDK3PDK4GPBAR1 | |
| SCHEMBL16735632 | 0.87 | PDK1 (0.43) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL16735666 | 0.83 | LMNA (0.53) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL16735668 | 0.82 | PDK1 (0.51) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL16735572 | 0.78 | PDK1 (0.51) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL16735601 | 0.78 | PDK1 (0.62) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735643 | 0.76 | LMNA (0.53) | PDK1PDK2PDK3PDK4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |