Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735676 | 0.92 | MAPT (0.48) | HTR2CMAPTNPC1HTTLMNA | |
| SCHEMBL16735646 | 0.84 | PDK1 (0.53) | HTR2CNPC1HTTLMNAPDK1 | |
| SCHEMBL16735643 | 0.83 | LMNA (0.53) | MAPTNPC1LMNAPDK1PDK2 | |
| SCHEMBL2143863 | 0.82 | HTR2C (0.51) | HTR2CMAPTNPC1HTTLMNA | |
| Quinoline SCHEMBL28311833 | 0.81 | HTR2C (0.52) | HTR2CMAPTNPC1HTTLMNA | |
| SCHEMBL16735601 | 0.78 | PDK1 (0.62) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735666 | 0.77 | LMNA (0.53) | MAPTHTTLMNAPDK1PDK2 | |
| SCHEMBL9092613 | 0.77 | HTR2C (0.56) | HTR2CMAPTNPC1HTTLMNA | |
| SCHEMBL2144207 | 0.74 | NPC1 (0.48) | HTR2CMAPTNPC1HTTLMNA | |
| SCHEMBL16735572 | 0.72 | PDK1 (0.51) | LMNAPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |