Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | CD74 | P04233 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735666 | 0.93 | LMNA (0.53) | LMNAPOLBALDH1A1TSHRKMT2A | |
| SCHEMBL16735646 | 0.87 | PDK1 (0.53) | LMNANPSR1POLBMEN1KMT2A | |
| SCHEMBL8137271 | 0.85 | RAB9A (0.64) | LMNANPSR1ALDH1A1RAB9AGAA | |
| SCHEMBL16735640 | 0.83 | HTR2C (0.51) | LMNAALDH1A1RAB9ANPC1PDK1 | |
| SCHEMBL16735676 | 0.83 | MAPT (0.48) | LMNANPSR1ALDH1A1RAB9AMEN1 | |
| SCHEMBL16735559 | 0.81 | HSP90AA1 (0.40) | LMNANPSR1POLBALDH1A1TSHR | |
| SCHEMBL16735572 | 0.81 | PDK1 (0.51) | LMNAALDH1A1RAB9AKDM4CL3MBTL1 | |
| SCHEMBL16735601 | 0.81 | PDK1 (0.62) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735668 | 0.81 | PDK1 (0.51) | LMNANPSR1ALDH1A1GAATSHR | |
| SCHEMBL16735553 | 0.79 | GPBAR1 (0.43) | POLBPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |