Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143863 | 0.92 | HTR2C (0.51) | NPC1MAPTHTTLMNAALDH1A1 | |
| SCHEMBL15715804 | 0.84 | ALDH1A1 (0.47) | NPC1MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL16735676 | 0.82 | MAPT (0.48) | NPC1MAPTHTTLMNAROCK1 | |
| SCHEMBL2143714 | 0.82 | POLB (0.56) | NPC1MAPTHTTLMNAALDH1A1 | |
| SCHEMBL2143843 | 0.78 | PDK1 (0.48) | MAPTHTTLMNAALDH1A1KMT2A | |
| SCHEMBL2143811 | 0.78 | PDK1 (0.48) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL2143814 | 0.78 | SLC22A12 (0.52) | NPC1ALDH1A1KMT2AHTR2CMEN1 | |
| SCHEMBL2143791 | 0.76 | POLB (0.53) | MAPTHTTLMNAALDH1A1KMT2A | |
| SCHEMBL2143846 | 0.76 | GPBAR1 (0.51) | MAPTALDH1A1KMT2AHTR2CMEN1 | |
| Quinoline SCHEMBL27786647 | 0.75 | ROCK1 (0.46) | NPC1MAPTHTTLMNAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | claimed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | claimed |
| EP-2345643-A1 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | claimed |
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | disclosed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | disclosed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | disclosed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | disclosed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | disclosed |
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | disclosed |
| EP-2345643-A1 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | disclosed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | TUBA8, SUCLG1, TUBB8 | NPC1 1244/4885MAPT 2844/4885HTT 3400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.