Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL16735616 | 0.87 | KMT2A (0.41) | PANK3KMT2AMEN1L3MBTL1PDK1 | |
| Bicarbonate SCHEMBL16735568 | 0.86 | KMT2A (0.39) | PANK3KMT2AMEN1L3MBTL1TRPV1 | |
| SCHEMBL1933212 | 0.85 | MEN1 (0.42) | PANK3KMT2AMEN1L3MBTL1PDK1 | |
| SCHEMBL10006505 | 0.85 | KMT2A (0.38) | PANK3KMT2AMEN1L3MBTL1DPP4 | |
| Bicarbonate SCHEMBL16735627 | 0.83 | FFAR2 (0.38) | TP53UBE2MDCUN1D1 | |
| Bicarbonate SCHEMBL9899636 | 0.82 | KMT2A (0.41) | PANK3KMT2AMEN1L3MBTL1TRPV1 | |
| SCHEMBL1932886 | 0.82 | L3MBTL1 (0.38) | PANK3KMT2AMEN1L3MBTL1PDK1 | |
| Bicarbonate SCHEMBL16735635 | 0.81 | KMT2A (0.47) | KMT2AMEN1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL1932882 | 0.80 | L3MBTL1 (0.38) | KMT2AMEN1L3MBTL1PDK1PDK2 | |
| Bicarbonate SCHEMBL16735610 | 0.80 | CCR3 (0.36) | TRPV1TP53MAPTUBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649045-B1 | SUBSTITUTED 1-BENZYLCYCLOALKYLCARBOXLIC ACIDS AND USE THEREOF | BAYER IP GMBH (DE) | 2015-05-27 | — | — | EP | disclosed |