Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9899636 | 0.93 | KMT2A (0.41) | KMT2AL3MBTL1MEN1PANK3TRPV1 | |
| Bicarbonate SCHEMBL16735635 | 0.92 | KMT2A (0.47) | KMT2AL3MBTL1MEN1SMN1; SMN2LMNA | |
| Bicarbonate SCHEMBL16735627 | 0.92 | FFAR2 (0.38) | FFAR2SLC6A2SLC6A3CCR3 | |
| Bicarbonate SCHEMBL16735549 | 0.91 | FFAR2 (0.38) | FFAR2LMNASLC6A2SLC6A3 | |
| Bicarbonate SCHEMBL16735568 | 0.91 | KMT2A (0.39) | KMT2AL3MBTL1MEN1PANK3TRPV1 | |
| Bicarbonate SCHEMBL16735547 | 0.91 | PTGES (0.40) | KMT2AMEN1TRPV1FFAR2SMN1; SMN2 | |
| Bicarbonate SCHEMBL16735651 | 0.90 | KMT2A (0.41) | KMT2AL3MBTL1MEN1PANK3SMN1; SMN2 | |
| Bicarbonate SCHEMBL16735546 | 0.89 | KMT2A (0.39) | KMT2AL3MBTL1MEN1PANK3TRPV1 | |
| Bicarbonate SCHEMBL16735653 | 0.89 | KMT2A (0.41) | KMT2AL3MBTL1MEN1LMNACCR3 | |
| Bicarbonate SCHEMBL16735610 | 0.87 | CCR3 (0.36) | TRPV1FFAR2LMNACCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649045-B1 | SUBSTITUTED 1-BENZYLCYCLOALKYLCARBOXLIC ACIDS AND USE THEREOF | BAYER IP GMBH (DE) | 2015-05-27 | — | — | EP | disclosed |