Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 7/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 7/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 7/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735572 | 0.87 | PDK1 (0.51) | GPBAR1CYP3A4CYP2C9PDK1PDK2 | |
| SCHEMBL16735668 | 0.85 | PDK1 (0.51) | GPBAR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735666 | 0.85 | LMNA (0.53) | GPBAR1CYP3A4CYP2C9PDK1PDK2 | |
| SCHEMBL2143846 | 0.83 | GPBAR1 (0.51) | GPBAR1CYP3A4CYP2C9PDK1PDK2 | |
| SCHEMBL16735601 | 0.81 | PDK1 (0.62) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735643 | 0.78 | LMNA (0.53) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL16735623 | 0.77 | SCD5 (0.44) | GPBAR1CYP3A4CYP2C9PDK1PDK2 | |
| SCHEMBL14403429 | 0.77 | CYP3A4 (0.43) | GPBAR1CYP3A4CYP2C9PDK1PDK2 | |
| SCHEMBL331761 | 0.77 | PDK1 (0.52) | GPBAR1CYP3A4CYP2C9PDK1PDK2 | |
| SCHEMBL16735676 | 0.76 | MAPT (0.48) | HTR2CMEN1KMT2ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |