Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735638 | 0.81 | MAOB (0.47) | PDK1LMNASMN1; SMN2MCL1TP53 | |
| SCHEMBL2143972 | 0.77 | ALDH1A1 (0.57) | EGLN1ALDH1A1TACR1TP53RAB9A | |
| SCHEMBL2143980 | 0.77 | ALDH1A1 (0.57) | EGLN1ALDH1A1TACR1TP53RAB9A | |
| SCHEMBL16735576 | 0.77 | ALDH1A1 (0.56) | ALDH1A1LMNATP53RAB9A | |
| SCHEMBL16735575 | 0.77 | HSP90AA1 (0.58) | PDK1ALDH1A1 | |
| SCHEMBL12522399 | 0.77 | ALDH1A1 (0.57) | EGLN1ALDH1A1TACR1TP53RAB9A | |
| SCHEMBL16735621 | 0.76 | TP53 (0.43) | PDK1ALDH1A1LMNASMN1; SMN2MCL1 | |
| SCHEMBL16735595 | 0.76 | MET (0.54) | PDK1ALDH1A1SMN1; SMN2MCL1MET | |
| SCHEMBL16735606 | 0.75 | PDK1 (0.47) | PDK1MCL1TP53RECQLRAB9A | |
| SCHEMBL28336465 | 0.74 | MCL1 (0.66) | EGLN1ALDH1A1LMNASMN1; SMN2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |