Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239308 | 0.88 | SMN1; SMN2 (0.34) | LOXL2SMN1; SMN2PDE4BLMNAMEN1 | |
| SCHEMBL20239206 | 0.88 | SMN1; SMN2 (0.37) | LOXL2F2SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL16738675 | 0.87 | MMP13 (0.32) | F2SMN1; SMN2RAB9ANPC1PDE4B | |
| SCHEMBL20239225 | 0.87 | LOXL2 (0.37) | LOXL2PDE4BMEN1KMT2AL3MBTL1 | |
| SCHEMBL20239292 | 0.86 | PTPN1 (0.33) | LOXL2F2SMN1; SMN2RAB9AMMP2 | |
| SCHEMBL16738668 | 0.86 | SMN1; SMN2 (0.43) | F2SMN1; SMN2RAB9ANPC1MMP2 | |
| SCHEMBL20239306 | 0.85 | PDE4B (0.34) | LOXL2F2SMN1; SMN2PDE4BMEN1 | |
| SCHEMBL16738672 | 0.83 | PDE2A (0.36) | F2SMN1; SMN2RAB9ANPC1MMP2 | |
| SCHEMBL16738665 | 0.82 | DGAT2 (0.44) | LOXL2F2SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL16738671 | 0.79 | SMN1; SMN2 (0.37) | SMN1; SMN2RAB9ANPC1PDE4BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| US-10053429-B2 | DGAT2 inhibitors | ELI LILLY AND COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| EP-3074381-B1 | NOVEL DGAT2 INHIBITORS | LILLY CO ELI (US) | 2018-07-04 | — | — | EP | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
| US-9073901-B2 | DGAT2 inhibitors | ELI LILLY AND COMPANY (US) | 2015-07-07 | — | — | US | disclosed |
| US-20150148358-A1 | NOVEL DGAT2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | LOXL2 2081/4885F2 2131/4885SMN1; SMN2 4828/4885 |
| US-20150148358-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | LOXL2 2031/4885F2 3676/4885SMN1; SMN2 4851/4885 |
| US-10053429-B2 | DGAT2 inhibitors | DGAT2, DGAT1, LCAT | LOXL2 1951/4885F2 1629/4885SMN1; SMN2 4835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.