Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 4/20 | 0.39 |
| ▸ | BMI1 | P35226 | 3/20 | 0.34 |
| ▸ | GALR1 | P47211 | 3/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.34 |
| ▸ | TUBB | P07437 | 3/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747897 | 0.89 | THRB (0.40) | GALR2GALR1TUBB4ATUBBTUBA3C | |
| SCHEMBL16740301 | 0.86 | TUBB4A (0.44) | GALR2BMI1GALR1TUBB4ATUBB | |
| SCHEMBL16747822 | 0.86 | GALR2 (0.41) | GALR2BMI1GALR1TUBB4ATUBB | |
| SCHEMBL16740327 | 0.85 | GALR2 (0.40) | GALR2BMI1GALR1TUBB4ATUBB | |
| SCHEMBL18094393 | 0.84 | PKM (0.39) | GALR2BMI1GALR1TUBB4ATUBB | |
| SCHEMBL16740085 | 0.84 | IRAK4 (0.43) | GALR2BMI1GALR1TUBB4ATUBB | |
| SCHEMBL16747824 | 0.83 | GALR2 (0.39) | GALR2BMI1GALR1TUBB4ATUBB | |
| SCHEMBL16740299 | 0.83 | BMI1 (0.40) | GALR2BMI1TUBB4ATUBBTUBA3C | |
| SCHEMBL16747825 | 0.81 | GALR2 (0.37) | GALR2BMI1GALR1TUBB4ATUBB | |
| SCHEMBL15742598 | 0.79 | GALR2 (0.41) | GALR2BMI1GALR1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |