Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 6/20 | 0.36 |
| ▸ | BCR | P11274 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | GALR2 | O43603 | 2/20 | 0.35 |
| ▸ | GALR1 | P47211 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747821 | 0.89 | GALR2 (0.39) | MAPTMEN1KMT2ASMN1; SMN2GALR2 | |
| SCHEMBL16747898 | 0.86 | ABL1 (0.42) | THRBBRAFMAPTMEN1NPC1 | |
| SCHEMBL16740137 | 0.84 | THRB (0.39) | THRBBRAFMAPTMEN1NPC1 | |
| SCHEMBL16740220 | 0.84 | PKM (0.40) | THRBBRAFMAPTMEN1NPC1 | |
| SCHEMBL16747889 | 0.84 | IRAK4 (0.45) | THRBBRAFMAPTMEN1NPC1 | |
| SCHEMBL16747903 | 0.82 | SCN5A (0.47) | THRBBRAFMAPTMEN1NPC1 | |
| SCHEMBL15742415 | 0.79 | KCNH2 (0.41) | THRBMAPTMEN1NPC1RAB9A | |
| SCHEMBL16740264 | 0.76 | ACP1 (0.47) | MAPTMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL16747822 | 0.75 | GALR2 (0.41) | MAPTMEN1KMT2ASMN1; SMN2GALR2 | |
| SCHEMBL16740211 | 0.75 | TUBB4A (0.46) | MAPTMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |