Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.68 |
| ▸ | POLB | P06746 | 6/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.68 |
| ▸ | BLM | P54132 | 5/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.68 |
| ▸ | ACHE | P22303 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | RECQL | P46063 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.60 |
| ▸ | THRB | P10828 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18136098 | 0.91 | MAPT (0.57) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL31400944 | 0.81 | ACHE (0.72) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL29588932 | 0.80 | MEN1 (0.76) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL2860609 | 0.80 | MEN1 (0.76) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL19636311 | 0.80 | ACHE (1.00) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL29407268 | 0.79 | ACHE (0.69) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL31400982 | 0.77 | MEN1 (0.67) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL13320834 | 0.73 | MEN1 (1.00) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL30319388 | 0.73 | MEN1 (1.00) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL30367913 | 0.73 | MEN1 (1.00) | MEN1POLBKMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10463664-B2 | Inhibitors of HSV nucleotidyl transferases and uses therefor | SAINT LOUIS UNIVERSITY (US) | 2019-11-05 | — | — | US | disclosed |
| US-10329542-B2 | HBV RNAse H purification and enzyme inhibitors | SAINT LOUIS UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20170335296-A1 | HBV RNASE H PURIFICATION AND ENZYME INHIBITORS | SAINT LOUIS UNIVERSITY (US) | 2017-11-23 | — | — | US | disclosed |
| US-20160296521-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2016-10-13 | — | — | US | disclosed |
| WO-2015077774-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170335296-A1 | HBV RNASE H PURIFICATION AND ENZYME INHIBITORS | RNASEH1, RNASE1, RNASEL | MEN1 2978/4885POLB 125/4885KMT2A 2785/4885 |
| US-20160296521-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | TYMP, TYMS, NAMPT | MEN1 2603/4885POLB 127/4885KMT2A 1441/4885 |
| US-10463664-B2 | Inhibitors of HSV nucleotidyl transferases and uses therefor | TYMP, TYMS, NAMPT | MEN1 2603/4885POLB 127/4885KMT2A 1441/4885 |
| US-10329542-B2 | HBV RNAse H purification and enzyme inhibitors | RNASEH1, RNASE1, RNASEL | MEN1 2978/4885POLB 125/4885KMT2A 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.