Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28858657 | 0.82 | TYR (0.53) | TYRMEN1CYP3A4HTTKMT2A | |
| SCHEMBL8400481 | 0.80 | TYR (0.58) | TYRMEN1CYP3A4HTTKMT2A | |
| SCHEMBL24804434 | 0.79 | HTT (0.50) | SRCPTPN1BACE1MEN1CYP3A4 | |
| SCHEMBL28075186 | 0.77 | MPO (0.47) | TSHRCYP2D6 | |
| SCHEMBL901087 | 0.77 | TYR (0.69) | TYRMEN1CYP3A4HTTKMT2A | |
| SCHEMBL10914582 | 0.77 | TYR (0.48) | TYRMEN1CYP3A4HTTKMT2A | |
| Amylmetacresol SCHEMBL29897625 | 0.75 | TYR (0.68) | TYRMEN1CYP3A4HTTKMT2A | |
| SCHEMBL14001444 | 0.75 | TYR (0.67) | TYRMEN1CYP3A4HTTKMT2A | |
| Butane SCHEMBL28342368 | 0.75 | TYR (0.67) | TYRMEN1CYP3A4HTTKMT2A | |
| Amylmetacresol SCHEMBL302197 | 0.75 | TYR (0.68) | TYRMEN1CYP3A4HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220105051-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2022-04-07 | — | — | US | disclosed |
| US-11197832-B2 | Curcuphenol compounds for increasing MHC-I expression | Cava Healthcare Inc. (CA) | 2021-12-14 | — | — | US | disclosed |
| US-20200375917-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | BIOMMUNE TECHNOLOGIES INC. (CA) | 2020-12-03 | — | — | US | disclosed |
| WO-2020154811-A9 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2020-09-17 | — | — | WO | disclosed |
| US-10751296-B2 | Curcuphenol compounds for increasing MHC-I expression | Cava Healthcare Inc. (CA) | 2020-08-25 | — | — | US | disclosed |
| WO-2020154811-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2020-08-06 | — | — | WO | disclosed |
| US-20170319508-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | Cava Healthcare Inc. (CA) | 2017-11-09 | — | — | US | disclosed |
| US-20150147314-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | JEFFERIES, WILFRED (CA) | 2015-05-28 | — | — | US | disclosed |
| US-20150147314-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | JEFFERIES, WILFRED (CA) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170319508-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | CD74, MICA, HLA-DRB1 | SRC 2209/4885TYR 3191/4885PTPN1 2945/4885 |
| US-10751296-B2 | Curcuphenol compounds for increasing MHC-I expression | CD74, MICA, HLA-DRB1 | SRC 2209/4885TYR 3191/4885PTPN1 2945/4885 |
| US-20220105051-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | HDAC1, TAP1, HDAC11 | SRC 2561/4885TYR 3290/4885PTPN1 2769/4885 |
| US-11197832-B2 | Curcuphenol compounds for increasing MHC-I expression | CD74, MICA, HLA-DRB1 | SRC 2209/4885TYR 3191/4885PTPN1 2945/4885 |
| US-20200375917-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | CD74, MICA, HLA-DRB1 | SRC 2209/4885TYR 3191/4885PTPN1 2945/4885 |
| US-20150147314-A1 | CURCUPHENOL COMPOUNDS FOR INCREASING MHC-I EXPRESSION | CD74, MICA, HLA-DRB1 | SRC 2209/4885TYR 3191/4885PTPN1 2945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.