Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | Q9HBH1 | 1/20 | 0.41 | |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16751979 | 0.76 | IDO1 (0.39) | RAB9ANPC1ALDH1A1SMN1; SMN2IDO1 | |
| SCHEMBL30721175 | 0.76 | HCAR3 (0.57) | GRM5TRPA1RAB9ANPC1ALDH1A1 | |
| SCHEMBL30321414 | 0.75 | DEGS1 (0.57) | RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29127158 | 0.75 | DEGS1 (0.57) | RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23536835 | 0.74 | NPC1 (0.61) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL209687 | 0.74 | FFAR2 (0.58) | FFAR2GRM5RAB9ANPC1ALDH1A1 | |
| SCHEMBL19699480 | 0.74 | FFAR2 (0.62) | FFAR2GRM5RAB9ANPC1ALDH1A1 | |
| SCHEMBL24103525 | 0.74 | RAB9A (0.54) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12596411 | 0.74 | HCAR3 (0.58) | GRM5TRPA1RAB9ANPC1ALDH1A1 | |
| SCHEMBL2513021 | 0.73 | GRM5 (0.46) | FFAR2GRM5TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896068-A1 | S1P3 ANTAGONISTS | Teva Pharmaceutical Industries Limited (IL) | 2021-10-20 | — | — | EP | disclosed |
| EP-3689864-A1 | S1P3 ANTAGONISTS | Teva Pharmaceutical Industries Limited (IL) | 2020-08-05 | — | — | EP | disclosed |
| EP-3086845-B1 | S1P3 ANTAGONISTS | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2019-11-20 | — | — | EP | disclosed |
| EP-2878339-A1 | SIP3 antagonists | Siena Biotech S.p.A. (IT) | 2015-06-03 | — | — | EP | disclosed |