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Proline

Proline

SCHEMBL3105891

NC(=O)CC[C@H](N)C(=O)OC(=O)[C@@H](N)CCC(N)=O.N[C@@H](COC(=O)[C@@H]1CCCN1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ BLM P54132 1/20 0.38
▸ PMP22 Q01453 1/20 0.38
▸ MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Valine SCHEMBL4398679 0.90 ALOX15 (0.31) KMT2AALOX15BLMPMP22
Proline SCHEMBL1675405 0.88 ALOX15 (0.41) KMT2AALOX15BLMPMP22
Proline SCHEMBL140698 0.87 TLR2 (0.34) KMT2ABLMMEN1
SCHEMBL17199760 0.84 ALOX15 (0.36) KMT2AALOX15BLMPMP22
SCHEMBL1275426 0.84 ALOX15 (0.38) KMT2AALOX15BLMPMP22
Glutamine SCHEMBL28174334 0.83 BLM (0.56) KMT2AALOX15BLMPMP22MEN1
Glutamine SCHEMBL1275425 0.83 BLM (0.56) KMT2AALOX15BLMPMP22MEN1
Glutamine SCHEMBL5789307 0.83 BLM (0.56) KMT2AALOX15BLMPMP22MEN1
Glutamine SCHEMBL7707543 0.83 BLM (0.56) KMT2AALOX15BLMPMP22MEN1
Glutamine SCHEMBL727085 0.83 BLM (0.56) KMT2AALOX15BLMPMP22MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7803522-B2 Elastin producing fibroblast formulations and methods of using the same HUMAN MATRIX SCIENCES, LLC (US) 2010-09-28 — — US disclosed
US-20080050346-A1 Elastin producing fibroblast formulations and methods of using the same NULASTIN, INC. 2008-02-28 — — US disclosed