Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | CARM1 | Q86X55 | 6/20 | 0.69 |
| ▸ | BCHE | P06276 | 2/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | P4HB | P07237 | 1/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16755490 | 1.00 | ACHE (0.73) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL16769887 | 1.00 | ACHE (0.73) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL19629172 | 0.90 | ACHE (0.74) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL19616006 | 0.87 | CARM1 (0.67) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL19616005 | 0.87 | CARM1 (0.67) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL19629107 | 0.87 | CARM1 (0.67) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL16755530 | 0.87 | ALDH1A1 (0.71) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL16755532 | 0.87 | ALDH1A1 (0.71) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL16769899 | 0.87 | ALDH1A1 (0.71) | ACHEALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL16755540 | 0.86 | ACHE (0.78) | ACHEALDH1A1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458607-B1 | METHOD FOR THE PROGNOSIS OF ACUTE PROMYELOCYTIC LEUKEMIA | EPI C S R L (IT) | 2021-10-06 | — | — | EP | disclosed |
| US-20190284635-A1 | METHOD FOR THE PROGNOSIS AND/OR TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA | EPI-C S.R.L. (IT) | 2019-09-19 | — | — | US | disclosed |
| EP-3458607-A1 | METHOD FOR THE PROGNOSIS AND/OR TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA | Epi-C S.r.L. (IT) | 2019-03-27 | — | — | EP | disclosed |
| US-9884825-B2 | Curcumin analogs and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| WO-2017198870-A1 | METHOD FOR THE PROGNOSIS AND/OR TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA | EPI-C S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | UNIVERSITY OF DELHI (IN) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284635-A1 | METHOD FOR THE PROGNOSIS AND/OR TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA | EZH2, KAT2A, EHMT2 | ACHE 4269/4885ALDH1A1 738/4885LMNA 3562/4885 |
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | COX15, HCCS, HMOX2 | ACHE 3174/4885ALDH1A1 94/4885LMNA 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.