Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054189 | 0.87 | L3MBTL1 (0.50) | L3MBTL1POLBRAB9ACHEK1RET | |
| SCHEMBL6566494 | 0.85 | RAB9A (0.48) | POLBRAB9ARETLMNATP53 | |
| SCHEMBL9051736 | 0.84 | TLR8 (0.51) | L3MBTL1POLBRAB9ACHEK1RET | |
| SCHEMBL10599732 | 0.83 | RAB9A (0.51) | L3MBTL1POLBRAB9ACHEK1RET | |
| SCHEMBL4948626 | 0.80 | L3MBTL1 (0.58) | L3MBTL1POLBRAB9ACHEK1RET | |
| SCHEMBL14217911 | 0.78 | L3MBTL1 (0.47) | L3MBTL1POLBRAB9ACHEK1RET | |
| SCHEMBL7395253 | 0.77 | POLB (0.55) | L3MBTL1POLBRAB9ACHEK1RET | |
| SCHEMBL12282618 | 0.76 | MAPT (0.53) | L3MBTL1POLBRAB9ALMNATP53 | |
| SCHEMBL11886170 | 0.76 | ADORA3 (0.55) | L3MBTL1POLBRAB9ACHEK1RET | |
| SCHEMBL5534364 | 0.75 | GAA (0.62) | L3MBTL1POLBRAB9ACHEK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034591-A1 | DIAMINOPYRAZOLE-CONTAINING COMPOSITIONS FOR COLOURING KERATIN FIBRES, COLOURING PROCESS, NOVEL DIAMINOPYRAZOLES AND METHOD FOR THEIR PREPARATION | L'OREAL (FR) | 1996-11-07 | — | — | WO | claimed |
| CN-103189378-B | As the Pyrazolopyridine ketone derivatives of LPA receptor antagonist | MERCK PATENT GMBH (DE) | 2016-03-02 | — | — | CN | disclosed |
| US-9067938-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2015-06-30 | — | — | US | disclosed |
| US-9067938-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2015-06-30 | — | — | US | disclosed |
| US-9067938-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2015-06-30 | — | — | US | disclosed |
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| EP-2611808-B1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| EP-2611808-B1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-8859775-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| EP-2611808-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | Merck Patent GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| CN-103189378-A | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH | 2013-07-03 | — | — | CN | disclosed |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| WO-2012028243-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028243-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |
| EP-1404288-A2 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A AMINO PYRAZOLE AND A CELLULOSE COMPOUND | L'OREAL (FR) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002051372-A2 | COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A AMINO PYRAZOLE AND A CELLULOSE COMPOUND | L'OREAL (FR) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | L3MBTL1 3955/4885POLB 2887/4885RAB9A 1419/4885 |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | L3MBTL1 3955/4885POLB 2887/4885RAB9A 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.