Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078331 | 0.73 | LMNA (0.38) | GAASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL6078736 | 0.70 | GAA (0.36) | GAASMN1; SMN2MEN1ALDH1A1TSHR | |
| SCHEMBL26694795 | 0.69 | MAPT (0.36) | GAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL6076839 | 0.68 | SMN1; SMN2 (0.35) | GAASMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL15074964 | 0.66 | OPRM1 (0.47) | MEN1KMT2APOLB | |
| SCHEMBL9675417 | 0.66 | SMN1; SMN2 (0.41) | GAASMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL25348114 | 0.66 | MEN1 (0.34) | GAASMN1; SMN2MEN1ALDH1A1TSHR | |
| SCHEMBL30782508 | 0.66 | MEN1 (0.34) | GAASMN1; SMN2MEN1ALDH1A1TSHR | |
| SCHEMBL25349844 | 0.66 | MEN1 (0.34) | GAASMN1; SMN2MEN1ALDH1A1TSHR | |
| SCHEMBL25348791 | 0.65 | LMNA (0.37) | GAASMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074386-A1 | NOVEL AMINO PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015079417-A1 | NOVEL AMINO PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2015-06-04 | — | — | WO | disclosed |