Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PPM1B | O75688 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26694795 | 0.92 | MAPT (0.36) | SMN1; SMN2GAAPPM1BPTPN1PPP1CC | |
| SCHEMBL10568510 | 0.85 | PPM1B (0.38) | SMN1; SMN2GAAPPM1BPTPN1PPP1CC | |
| SCHEMBL6078331 | 0.77 | LMNA (0.38) | SMN1; SMN2GAAOPRM1MAPTPOLB | |
| SCHEMBL16671106 | 0.76 | MAPT (0.38) | PPM1BPTPN1PPP1CCMAPTPKM | |
| SCHEMBL6078736 | 0.74 | GAA (0.36) | SMN1; SMN2GAAOPRM1MAPTPOLB | |
| SCHEMBL6076839 | 0.72 | SMN1; SMN2 (0.35) | SMN1; SMN2GAAOPRM1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL27346924 | 0.72 | GAA (0.36) | SMN1; SMN2GAAOPRM1 | |
| SCHEMBL6921588 | 0.70 | SMN1; SMN2 (0.60) | SMN1; SMN2GAAOPRM1MAPTPKM | |
| SCHEMBL13730327 | 0.66 | PPM1B (0.40) | PPM1BPTPN1PPP1CCMAPTPKM | |
| SCHEMBL16759728 | 0.66 | GAA (0.33) | SMN1; SMN2GAAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275092-B1 | PROCESS FOR PREPARING (+)-1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1,7-DICARBOXYLATES | SYNTEX (U.S.A.) INC. (US) | 1992-06-03 | — | — | EP | disclosed |
| US-4874872-A | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-17 | — | — | US | disclosed |
| US-4849526-A | Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0275092-A1 | Process for preparing (+)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1988-07-20 | — | — | EP | disclosed |