Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078331 | 0.82 | LMNA (0.38) | GAASMN1; SMN2POLBOPRM1LMNA | |
| SCHEMBL26694795 | 0.78 | MAPT (0.36) | GAASMN1; SMN2POLBOPRM1MAPT | |
| SCHEMBL6076839 | 0.77 | SMN1; SMN2 (0.35) | GAASMN1; SMN2POLBOPRM1LMNA | |
| SCHEMBL9675417 | 0.74 | SMN1; SMN2 (0.41) | GAASMN1; SMN2POLBOPRM1KDM4E | |
| SCHEMBL6921588 | 0.71 | SMN1; SMN2 (0.60) | GAASMN1; SMN2OPRM1KDM4EMEN1 | |
| SCHEMBL16759728 | 0.70 | GAA (0.33) | GAASMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL25348791 | 0.70 | LMNA (0.37) | GAASMN1; SMN2POLBOPRM1LMNA | |
| SCHEMBL1169368 | 0.70 | SMN1; SMN2 (0.56) | GAASMN1; SMN2POLBOPRM1LMNA | |
| SCHEMBL1054957 | 0.69 | POLB (0.36) | GAASMN1; SMN2POLBOPRM1LMNA | |
| SCHEMBL31105354 | 0.69 | POLB (0.36) | GAASMN1; SMN2POLBOPRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | GAA 4576/4885SMN1; SMN2 4395/4885POLB 2995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.