Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16767306 | 0.88 | OPRM1 (0.38) | BACE1KCNH2PABPC1OPRM1OPRL1 | |
| SCHEMBL16767140 | 0.84 | BACE1 (0.43) | BACE1KCNH2OPRL1ACHEHTT | |
| SCHEMBL16767620 | 0.82 | ALDH1A1 (0.34) | BACE1KCNH2PABPC1ACHEKDM4E | |
| SCHEMBL16767703 | 0.81 | KCNH2 (0.38) | BACE1KCNH2PABPC1OPRM1OPRL1 | |
| SCHEMBL16767685 | 0.80 | OPRM1 (0.43) | BACE1KCNH2OPRM1OPRL1ACHE | |
| SCHEMBL28081426 | 0.78 | KDM1A (0.39) | BACE1KCNH2PABPC1ACHEKDM4E | |
| SCHEMBL695073 | 0.77 | ALDH1A1 (0.49) | KDM4EMEN1GAAKMT2A | |
| SCHEMBL16767453 | 0.77 | BACE1 (0.38) | BACE1KCNH2PABPC1OPRM1OPRL1 | |
| SCHEMBL16767396 | 0.75 | BACE1 (0.36) | BACE1KCNH2PABPC1OPRM1OPRL1 | |
| SCHEMBL18187489 | 0.75 | PABPC1 (0.34) | BACE1KCNH2PABPC1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-02 | — | — | US | disclosed |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-01-31 | — | — | US | disclosed |
| EP-3077378-B1 | N-CYCLOPROPYL-N-{[2-(1-SUBSTITUTEDCYCLOPROPYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-10 | — | — | US | disclosed |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-03 | — | — | US | disclosed |
| EP-3077377-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-3077378-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082587-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015082586-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | BACE1 2709/4885KCNH2 986/4885PABPC1 3885/4885 |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | BACE1 2597/4885KCNH2 1032/4885PABPC1 4070/4885 |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | BACE1 2709/4885KCNH2 986/4885PABPC1 3885/4885 |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | BACE1 2637/4885KCNH2 994/4885PABPC1 3962/4885 |
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | BACE1 2709/4885KCNH2 986/4885PABPC1 3885/4885 |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NAT1, NANP | BACE1 2373/4885KCNH2 874/4885PABPC1 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.