Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11787110 | 0.93 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMEN1GAA | |
| SCHEMBL23545671 | 0.85 | TAAR1 (0.44) | ALDH1A1KDM4EMAPTMEN1GAA | |
| SCHEMBL27790129 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EMAPTMEN1USP2 | |
| SCHEMBL5736421 | 0.82 | CYP1A2 (0.43) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13137123 | 0.82 | OPRM1 (0.47) | ALDH1A1KDM4EMAPTMEN1USP2 | |
| SCHEMBL14036805 | 0.81 | MEN1 (0.40) | KDM4EMEN1GAAKMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL10446825 | 0.80 | OPRM1 (0.46) | ALDH1A1KDM4EMAPTMEN1USP2 | |
| SCHEMBL13262996 | 0.80 | KDM1A (0.59) | ALDH1A1KDM4EMEN1GAACASP1 | |
| SCHEMBL23545638 | 0.80 | CYP1A2 (0.43) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30471887 | 0.80 | CYP1A2 (0.43) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635551-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2018-05-02 | — | — | EP | disclosed |
| CN-103402970-B | Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation | 拜耳知识产权有限责任公司 | 2017-02-15 | — | — | CN | disclosed |
| US-9260378-B2 | Process for the preparation of substituted N-(benzyl)cyclopropanamines by imine hydrogenation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-16 | — | — | US | disclosed |
| US-9260378-B2 | Process for the preparation of substituted N-(benzyl)cyclopropanamines by imine hydrogenation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-16 | — | — | US | disclosed |
| US-9260378-B2 | Process for the preparation of substituted N-(benzyl)cyclopropanamines by imine hydrogenation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-16 | — | — | US | disclosed |
| EP-2635551-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | Bayer Cropscience AG (DE) | 2013-09-11 | — | — | EP | disclosed |
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2013-08-22 | — | — | US | disclosed |
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2013-08-22 | — | — | US | disclosed |
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2013-08-22 | — | — | US | disclosed |
| WO-2012059585-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012059585-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | WO | disclosed |
| US-20120115907-A1 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-05-10 | — | — | US | disclosed |
| EP-2421828-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN | Cadila Healthcare Limited (IN) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122580-A2 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| EP-1761509-A2 | SUBSTITUTED CYCLOALKYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005111002-A2 | SUBSTITUTED CYCLOALKYL DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115907-A1 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | REN, ACE, AGTR1 | ALDH1A1 1307/4885KDM4E 4001/4885MAPT 202/4885 |
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | DHPS, PNMT, INMT | ALDH1A1 648/4885KDM4E 2087/4885MAPT 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.