Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 6/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16755582 | 1.00 | HSD11B1 (0.48) | HSD11B1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL16755580 | 1.00 | HSD11B1 (0.48) | HSD11B1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL16755581 | 0.90 | KMT2A (0.49) | KMT2AALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL16769875 | 0.90 | KMT2A (0.49) | KMT2AALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL16755583 | 0.90 | KMT2A (0.49) | KMT2AALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL19840306 | 0.88 | ACHE (0.48) | HSD11B1KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL16755587 | 0.88 | ACHE (0.48) | HSD11B1KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL15561380 | 0.88 | ACHE (0.48) | HSD11B1KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL16769879 | 0.88 | KMT2A (0.47) | KMT2AALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL16755542 | 0.88 | KMT2A (0.47) | KMT2AALDH1A1MAPTMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884825-B2 | Curcumin analogs and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884825-B2 | Curcumin analogs and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | UNIVERSITY OF DELHI (IN) | 2015-06-04 | — | — | US | disclosed |
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | UNIVERSITY OF DELHI (IN) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | COX15, HCCS, HMOX2 | HSD11B1 766/4885KMT2A 2801/4885ALDH1A1 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.