Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233437 | 0.81 | AOC3 (0.43) | TRPA1LMNARIPK1HRH1HTR2A | |
| SCHEMBL27522096 | 0.79 | HRH1 (0.56) | RIPK1HRH1HTR2AALDH1A1TAAR1 | |
| SCHEMBL13513553 | 0.79 | TRPA1 (0.44) | TRPA1LMNAHRH1KDM4EALDH1A1 | |
| SCHEMBL5560718 | 0.79 | TRPA1 (0.44) | TRPA1LMNARIPK1HRH1KDM4E | |
| SCHEMBL28609634 | 0.78 | POLB (0.42) | LMNAHRH1HTR2AKDM4EALDH1A1 | |
| SCHEMBL3432105 | 0.78 | POLB (0.42) | LMNAHRH1HTR2AKDM4EALDH1A1 | |
| SCHEMBL27522125 | 0.76 | HRH1 (0.59) | HRH1HTR2ATAAR1 | |
| SCHEMBL27529939 | 0.76 | HTR2A (0.62) | LMNAHRH1HTR2AKDM4EALDH1A1 | |
| SCHEMBL3144258 | 0.76 | LMNA (0.48) | TRPA1LMNAHRH1HTR2ATAAR1 | |
| SCHEMBL28607657 | 0.76 | LMNA (0.48) | TRPA1LMNAHRH1HTR2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1891220-A | Use of 2-amino-3-alkylpyrimidinone derivatives for producing medicaments | SANOFI SYNTHELABO (FR) | 2007-01-10 | — | — | CN | claimed |
| CN-1247567-C | 2-amino-3-alkylpyrimidinone derivatives as GSK3 beta inhibitors | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | CN | claimed |
| EP-3184112-B1 | SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE | FUJIFILM CORP (JP) | 2020-12-23 | — | — | EP | disclosed |
| US-20170290929-A1 | GRP78 TARGETED CONJUGATES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2017-10-12 | — | — | US | disclosed |
| EP-3184112-A1 | SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-SS-D-ARABINOFURANOSYL)CYTOSINE | Fujifilm Corporation (JP) | 2017-06-28 | — | — | EP | disclosed |
| EP-2883866-A1 | INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES | FUJIFILM Corporation (JP) | 2015-06-17 | — | — | EP | disclosed |
| CN-1891220-A | Use of 2-amino-3-alkylpyrimidinone derivatives for producing medicaments | SANOFI SYNTHELABO (FR) | 2007-01-10 | — | — | CN | disclosed |
| CN-1247567-C | 2-amino-3-alkylpyrimidinone derivatives as GSK3 beta inhibitors | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | CN | disclosed |
| CN-1419552-A | 2-amino-3-alkylpyrimidinone derivatives as GSK3 beta inhibitors | SANOFI SYNTHELABO (FR) | 2003-05-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170290929-A1 | GRP78 TARGETED CONJUGATES | HSPA5, ERP44, PDIA5 | TRPA1 4122/4885LMNA 2261/4885RIPK1 4147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.