Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20468614 | 0.87 | CYP19A1 (0.39) | CYP19A1GAAKDM4ENPC1ALDH1A1 | |
| SCHEMBL16772539 | 0.84 | SMN1; SMN2 (0.40) | CYP19A1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL16755703 | 0.78 | CYP3A4 (0.44) | CYP19A1GAAKDM4ENPC1ALDH1A1 | |
| SCHEMBL28344489 | 0.72 | DRD2 (0.38) | CYP19A1GAAKDM4ENPC1ALDH1A1 | |
| SCHEMBL9037851 | 0.71 | AKR1B1 (0.56) | TP53RAB9A | |
| SCHEMBL20465468 | 0.71 | SMN1; SMN2 (0.39) | CYP19A1GAAKDM4EALDH1A1MAPT | |
| SCHEMBL9039157 | 0.71 | AKR1B1 (0.53) | RAB9A | |
| SCHEMBL4641423 | 0.70 | DRD2 (0.41) | CYP19A1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL31371868 | 0.70 | DRD2 (0.41) | CYP19A1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL31371949 | 0.70 | DRD2 (0.44) | CYP19A1KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957247-B2 | SecA inhibitors and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20150152077-A1 | SecA Inhibitors and Methods of Making and Using Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152077-A1 | SecA Inhibitors and Methods of Making and Using Thereof | SEC61B, SEC61A1, SEC23A | TP53 3949/4885CYP19A1 2351/4885GAA 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.