Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.50 |
| ▸ | RXRB | P28702 | 5/20 | 0.50 |
| ▸ | ADH5 | P11766 | 7/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194664 | 0.90 | RXRA (0.62) | RXRARXRBADH5ALOX15TSHR | |
| SCHEMBL16775454 | 0.86 | RXRA (0.54) | RXRARXRBALOX15ALDH1A1 | |
| SCHEMBL16775436 | 0.85 | RXRA (0.49) | RXRARXRBADH5ALDH1A1SMN1; SMN2 | |
| SCHEMBL182330 | 0.82 | TUBB4A (0.48) | RXRARXRBADH5ALOX15ALDH1A1 | |
| SCHEMBL182280 | 0.81 | ADH5 (0.55) | RXRARXRBADH5ALDH1A1SMN1; SMN2 | |
| SCHEMBL182188 | 0.81 | ADH5 (0.55) | RXRARXRBADH5ALOX15TSHR | |
| SCHEMBL182269 | 0.81 | RXRA (0.49) | RXRARXRBADH5RXRGSRD5A2 | |
| SCHEMBL10195813 | 0.79 | ADH5 (0.63) | RXRARXRBADH5TSHRRXRG | |
| SCHEMBL16775440 | 0.78 | ADH5 (0.54) | RXRARXRBADH5ALDH1A1HPGD | |
| SCHEMBL186326 | 0.77 | BCL2L1 (0.51) | RXRARXRBADH5RXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051342-B2 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases | PTC THERAPEUTICS, INC. (US) | 2015-06-09 | — | — | US | disclosed |