Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.49 |
| ▸ | RXRB | P28702 | 5/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | BAD | Q92934 | 1/20 | 0.45 |
| ▸ | ADH5 | P11766 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186326 | 0.90 | BCL2L1 (0.51) | RXRARXRBBCL2L1BADADH5 | |
| SCHEMBL16775452 | 0.86 | KMO (0.43) | RXRARXRBKDM4ELMNAHSD17B10 | |
| SCHEMBL16775451 | 0.85 | RXRA (0.50) | RXRARXRBADH5HPGDALDH1A1 | |
| SCHEMBL182330 | 0.81 | TUBB4A (0.48) | RXRARXRBADH5KDM4EHSD17B10 | |
| SCHEMBL182600 | 0.81 | BCL2L1 (0.47) | BCL2L1BADADH5KDM4ELMNA | |
| SCHEMBL182280 | 0.80 | ADH5 (0.55) | RXRARXRBADH5KDM4ELMNA | |
| SCHEMBL2710630 | 0.80 | BCL2L1 (0.62) | RXRARXRBBCL2L1BADADH5 | |
| SCHEMBL180989 | 0.79 | ADH5 (0.48) | RXRARXRBBCL2L1BADADH5 | |
| SCHEMBL10195813 | 0.78 | ADH5 (0.63) | RXRARXRBBCL2L1BADADH5 | |
| SCHEMBL10194664 | 0.77 | RXRA (0.62) | RXRARXRBBCL2L1BADADH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051342-B2 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases | PTC THERAPEUTICS, INC. (US) | 2015-06-09 | — | — | US | disclosed |