Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | THRA | P10827 | 5/20 | 0.60 |
| ▸ | THRB | P10828 | 5/20 | 0.60 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.60 |
| ▸ | TACR2 | P21452 | 2/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | SHBG | P04278 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30110959 | 1.00 | ALDH1A1 (0.70) | ALDH1A1HSD17B10HPGDTHRATHRB | |
| SCHEMBL18527374 | 0.98 | ALDH1A1 (0.72) | ALDH1A1HSD17B10HPGDTHRATHRB | |
| SCHEMBL11271830 | 0.92 | ALDH1A1 (0.71) | ALDH1A1HSD17B10HPGDTHRATHRB | |
| SCHEMBL12967436 | 0.92 | THRA (0.60) | ALDH1A1THRATHRBRARBMEN1 | |
| SCHEMBL28943035 | 0.87 | ALDH1A1 (0.55) | ALDH1A1HSD17B10HPGDTHRATHRB | |
| SCHEMBL16267306 | 0.86 | ALDH1A1 (0.72) | ALDH1A1HSD17B10HPGDTHRATHRB | |
| SCHEMBL6801680 | 0.85 | ALDH1A1 (0.96) | ALDH1A1HSD17B10HPGDTHRATHRB | |
| SCHEMBL8337401 | 0.85 | ALDH1A1 (0.96) | ALDH1A1HSD17B10HPGDTHRATHRB | |
| SCHEMBL19166899 | 0.85 | GPR84 (0.70) | ALDH1A1HSD17B10THRATHRBESR1 | |
| SCHEMBL2674656 | 0.85 | ALDH1A1 (0.96) | ALDH1A1HSD17B10HPGDTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ALDH1A1 1726/4885HSD17B10 2085/4885HPGD 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.