Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.33 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776198 | 0.83 | GRM5 (0.39) | KCNH2HRH3 | |
| SCHEMBL16776200 | 0.82 | FAAH (0.39) | KCNH2HRH3 | |
| SCHEMBL16776264 | 0.82 | SLC27A1 (0.35) | NPC1RAB9ASMN1; SMN2PIK3CAPIK3CD | |
| SCHEMBL16776207 | 0.80 | GSK3B (0.37) | KCNH2HRH3KDM4EMAPT | |
| SCHEMBL16776209 | 0.79 | KCNH2 (0.42) | NPC1RAB9ASMN1; SMN2KCNH2HRH3 | |
| SCHEMBL16775986 | 0.79 | SLC27A1 (0.36) | NPC1RAB9ASMN1; SMN2PIK3CAPIK3CD | |
| SCHEMBL16775978 | 0.78 | MLNR (0.38) | — | |
| SCHEMBL16776023 | 0.78 | GSK3B (0.36) | NPC1RAB9AKCNH2HRH3KDM4E | |
| SCHEMBL16776014 | 0.78 | GRM5 (0.40) | KCNH2HRH3 | |
| SCHEMBL17618711 | 0.75 | SMN1; SMN2 (0.38) | NPC1RAB9ASMN1; SMN2ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | NPC1 3380/4885RAB9A 1471/4885SMN1; SMN2 2122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.