Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.36 |
| ▸ | HTR2B | P41595 | 10/20 | 0.36 |
| ▸ | HTR2A | P28223 | 10/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775826 | 0.94 | CA2 (0.40) | HTR2CHTR2BHTR2ACYP1A2CA2 | |
| SCHEMBL16785651 | 0.91 | CA2 (0.39) | HTR2CHTR2BHTR2ACYP1A2CA2 | |
| SCHEMBL16776011 | 0.89 | CA9 (0.38) | HTR2CHTR2BHTR2ACA9MEN1 | |
| SCHEMBL16775916 | 0.87 | FAAH (0.38) | HTR2CHTR2AMEN1LMNATP53 | |
| SCHEMBL16776000 | 0.85 | PRKCI (0.39) | RPS6KA3RPS6KA2 | |
| SCHEMBL16785649 | 0.85 | CA2 (0.39) | HTR2CHTR2BHTR2ACYP1A2CA2 | |
| SCHEMBL16775829 | 0.84 | CA2 (0.41) | HTR2CHTR2ACA2CA9SLC5A1 | |
| SCHEMBL16776185 | 0.84 | HTR2C (0.40) | HTR2CHTR2BHTR2ACYP1A2KDM4E | |
| SCHEMBL16776025 | 0.84 | CYP11B2 (0.38) | HTR2CHTR2BHTR2ACYP1A2 | |
| SCHEMBL16775824 | 0.84 | HTR2A (0.50) | HTR2CHTR2BHTR2ACYP1A2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HTR2C 4651/4885HTR2B 4224/4885HTR2A 4386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.