SCHEMBL1677879

SCHEMBL1677879

O=C(O)/C=C/C(=O)c1ccc(Cl)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.67
ALDH1A1 P00352 5/20 0.67
KMT2A Q03164 1/20 0.67
HPGD P15428 3/20 0.64
NPSR1 Q6W5P4 3/20 0.64
HTT P42858 3/20 0.64
LMNA P02545 2/20 0.64
THRB P10828 1/20 0.64
CYP1B1 Q16678 1/20 0.61
CYP1A2 P05177 1/20 0.58
ALOX12 P18054 1/20 0.58
CYP2C19 P33261 1/20 0.58
MAOB P27338 3/20 0.56
CXCL12 P48061 2/20 0.55
ALOX15 P16050 1/20 0.54
TSHR P16473 1/20 0.54
MAOA P21397 1/20 0.53
MAPK1 P28482 1/20 0.51
PLA2G1B P04054 1/20 0.50
ATG4B Q9Y4P1 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1677880 1.00 MAPT (0.67) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL7370645 0.94 MAPT (0.60) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL6998661 0.91 MAPT (0.67) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL6998663 0.91 MAPT (0.67) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL11018799 0.89 MAPT (0.55) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL10937052 0.89 MAPT (0.55) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL10937055 0.89 MAPT (0.55) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL11018812 0.89 MAPT (0.55) MAPTALDH1A1KMT2AHPGDNPSR1
SCHEMBL29130643 0.87 MAOB (0.72) MAPTALDH1A1HPGDNPSR1HTT
SCHEMBL11621360 0.81 MAPT (0.56) MAPTALDH1A1KMT2AHPGDNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1747059-A1 PERVAPORATION COMPOSITE MEMBRANES McMaster University (CA) 2007-01-31 EP claimed
US-20060000778-A1 high-performance membrane designed for the selective removal of a polar fluid (water) from less polar fluids (organic solvents), by a pervaporation using a composite membrane contaiing ultrafiltration membrane as support ( e.g. cellulose acetate) and a crosslinked copolymer of anionic, cationic monomers MCMASTER UNIVERSITY (CA) 2006-01-05 US claimed
WO-2005102503-A1 PERVAPORATION COMPOSITE MEMBRANES MCMASTER UNIVERSITY (CA) 2005-11-03 WO claimed
US-20050239853-A1 New compounds BIOVITRUM AB (SE) 2005-10-27 US claimed
WO-2005075471-A2 THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS BIOVITRUM AB (SE) 2005-08-18 WO claimed
EP-3802122-B1 METHOD OF MAKING AN ANTIMICROBIAL MULTILAYER FILM CRYOVAC LLC (US) 2023-08-16 EP disclosed
US-11325357-B2 Method of making an antimicrobial multilayer film CRYOVAC, LLC (US) 2022-05-10 US disclosed
US-20210213713-A1 METHOD OF MAKING AN ANTIMICROBIAL MULTILAYER FILM CRYOVAC, LLC 2021-07-15 US disclosed
EP-2226192-B1 DRYING SUBSTANCES, PREPARATION AND USE THEREOF ORIDION MEDICAL 1987 LTD (IL) 2016-08-31 EP disclosed
EP-2226116-B1 Drying tube, preparation and use thereof ORIDION MEDICAL 1987 LTD (IL) 2016-04-20 EP disclosed
US-20150283519-A1 DRYING SUBSTANCES, PREPARATION AND USE THEREOF ORIDION MEDICAL 1987 LTD. (IL) 2015-10-08 US disclosed
US-9090766-B2 Drying substances, preparation and use thereof ORIDION MEDICAL 1987 LTD. (IL) 2015-07-28 US disclosed
US-4594197-A 3-benzoyl-2-mercaptopropionic acid derivatives TAISHO PHARMACEUTICAL CO., LTD. (JP) 1986-06-10 US disclosed
EP-0138349-A1 3-Benzoyl-2-mercaptopropionic acid derivaties TAISHO PHARMACEUTICAL CO. LTD (JP) 1985-04-24 EP disclosed
US-4483868-A ANTIULCER AGENTS ANTISECRETORY AGENTS ROUSSEL UCLAF (FR) 1984-11-20 US disclosed
US-4374249-A HYPOTENSIVE AGENTS AMERICAN CYANAMID COMPANY (US) 1983-02-15 US disclosed
US-4221804-A Mercaptoacyldihydropyrazole carboxylic acid derivatives ROVNYAK GEORGE C 1980-09-09 US disclosed
US-4211786-A Mercaptoacyldihydropyrazole carboxylic acid derivatives E. R. SQUIBB & SONS, INC. (US) 1980-07-08 US disclosed
US-4127656-A Method of inhibiting lipogensis with 3-(benzoyl)oxiranecarboxamides SHELL OIL COMPANY (US) 1978-11-28 US disclosed
US-4091221-A LIPOGENESIS INHIBITORS SHELL OIL COMPANY (US) 1978-05-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050239853-A1 New compounds HSD11B1, CYP11B1, HSD3B1 MAPT 3607/4885ALDH1A1 67/4885KMT2A 3213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.