Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.59 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.52 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.52 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.52 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31197199 | 1.00 | TRPA1 (0.59) | TRPA1GPR52RAB9AALDH1A1LMNA | |
| SCHEMBL9928581 | 0.91 | CYP3A4 (0.57) | TRPA1GPR52RAB9AALDH1A1LMNA | |
| SCHEMBL31197198 | 0.85 | TLR4 (0.46) | GPR52RAB9AALDH1A1LMNAMEN1 | |
| SCHEMBL30543062 | 0.83 | CYP3A4 (0.52) | TRPA1GPR52RAB9AALDH1A1LMNA | |
| SCHEMBL29850441 | 0.83 | CYP3A4 (0.52) | TRPA1GPR52RAB9AALDH1A1LMNA | |
| SCHEMBL5632468 | 0.83 | GPR52 (0.54) | TRPA1GPR52RAB9AALDH1A1LMNA | |
| SCHEMBL9954124 | 0.83 | TRPA1 (0.63) | TRPA1RAB9AALDH1A1LMNAMEN1 | |
| SCHEMBL3848013 | 0.83 | TRPA1 (0.63) | TRPA1RAB9AALDH1A1LMNAMEN1 | |
| SCHEMBL30742787 | 0.82 | GPR52 (0.48) | GPR52RECQLMAOB | |
| SCHEMBL108688 | 0.82 | GPR52 (0.48) | GPR52RECQLMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850261-B2 | Silicon-based cross coupling agents and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170210766-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-07-27 | — | — | US | disclosed |
| US-9499660-B2 | Silicon-based cross coupling agents and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-11-22 | — | — | US | disclosed |
| WO-2016011231-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-01-21 | — | — | WO | disclosed |
| US-20150152216-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210766-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | RAD51, CA1, DCLRE1A | TRPA1 4234/4885GPR52 4707/4885RAB9A 3757/4885 |
| US-20150152216-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | RAD51, CA1, DCLRE1A | TRPA1 4234/4885GPR52 4707/4885RAB9A 3757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.