Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.32 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229772 | 0.93 | AXL (0.37) | SLC6A9AXLTYRO3MERTKGALR3 | |
| SCHEMBL16229806 | 0.91 | DGAT1 (0.35) | SLC6A9ALKHTR6ERBB2ERBB4 | |
| SCHEMBL16229798 | 0.90 | HTR6 (0.36) | SLC6A9HTR6HTR1AHTR7 | |
| SCHEMBL16229761 | 0.90 | SLC6A9 (0.37) | SLC6A9HTR6 | |
| SCHEMBL16229810 | 0.89 | SLC6A9 (0.38) | SLC6A9AXLTYRO3MERTKGALR3 | |
| SCHEMBL16784648 | 0.89 | SLC6A9 (0.42) | SLC6A9AXLTYRO3MERTKGALR3 | |
| SCHEMBL16229811 | 0.86 | SLC6A9 (0.50) | SLC6A9 | |
| SCHEMBL16784636 | 0.84 | GALR3 (0.41) | SLC6A9AXLTYRO3MERTKGALR3 | |
| SCHEMBL16229795 | 0.84 | GALR3 (0.35) | SLC6A9AXLTYRO3MERTKGALR3 | |
| SCHEMBL16229802 | 0.84 | GALR3 (0.38) | SLC6A9GALR3TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |